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Serum HBV RNA as a Predictor of Peginterferon Alfa-2a (40KD) Response in Patients With HBeAg-Positive ChronicHepatitis B.
PubMed
van Bömmel, Florian; van Bömmel, Alena; Krauel, Alexander; Wat, Cynthia; Pavlovic, Vedran; Yang, Lei; Deichsel, Danilo; Berg, Thomas; Böhm, Stephan
2018-05-08
Hepatitis B virus (HBV) RNA is a novel serum biomarker that has the potential to predict treatment response in patients with chronichepatitis B. We explored whether HBV RNA serum levels can predict hepatitis B e antigen (HBeAg) seroconversion in patients treated with peginterferon alfa-2a. Serum samples from HBeAg-positive patients previously treated with peginterferon alfa-2a in two large randomized controlled trials were retrospectively analyzed. HBV RNA levels were measured using a real-time polymerase chain reaction assay. Ability of individual biomarkers to predict HBeAg seroconversion at 24 weeks post-treatment was evaluated using receiver operating characteristics (ROC) analyses. The study included 131 subjects (70% male, 96% Asians, 35% HBV genotypes B and 61% C), 76 treated with peginterferon alfa-2a alone and 55 in combination with LAM. Median HBV RNA levels were significantly lower, at all time points, in patients achieving HBeAg seroconversion. Levels of HBV RNA at treatment we
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Vitamin B12 equitable associ
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Items where Subject is "WC Communicable Diseases > Tropical and Parasitic Diseases > WC 695 Parasitic diseases (General)"
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Abdi, Abdirahman I, Kariuki, Symon M, Muthui, Michelle K, Kivisi, Cheryl A, Gregory, Fegan, Gitau, Evelyn, Charles R, Newton and Peter C, Bull (2015) 'Differential Plasmodium falciparum surface antigen expression among children with Malarial Retinopathy'. Scientific Reports, Vol 5, Issue 18034.
Add, Editor (2013) Manson's Tropical Diseases Twenty-Third Edition, London, Elsevier Saunders.
Adekeye, Oluwatosin, Chowdhury, Shahreen, McRae, Ayuba, Olorunfemi, Temitope, Ozokede, Edward, Dubukumah, Linda, Makinde, Oluwabunmi, Ewemade, Jude, Abdulkadir, Shuaibu, Ayuba, Rebecca, Habibat, Suleiman, Gurma, Matthew, Thomson, Rachael, Isiyaku, Sunday and Dean, LauraORCID: https://orcid.org/0000-0002-4910-9707 (2023) 'Exploring the well-being of people affected by skin NTDs in Kaduna and Kwara States, Nigeria: a photovoice and scoping review study'. International Health, Vol 15, Issue Supplement 1, i100-i109.
Agonhossou, Romuald, Akoton, Romaric, Dossou, Yannelle A, Avok